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目的:探讨转甲状腺蛋白(TTR)与s PE及FGR发病的关系及意义。方法:选取2012年9月1日至2015年2月1日在首都医科大学附属北京潞河医院产检并住院分娩的单胎孕妇120例,将患者分为4组:FGR组、s PE组、s PE+FGR组和对照组(各30例)。ELISA法检测TTR浓度。比较4组患者的年龄、孕次、产次、孕周、母血清TTR浓度等指标。结果:4组患者的年龄、孕次、产次、孕周等比较,差异无统计学意义(P>0.05)。FGR组、s PE组及s PE+FGR组的母血TTR浓度较对照组明显降低,差异有统计学意义(P<0.01)。s PE组血清中TTR含量低于FGR组,差异有统计学意义(P<0.01)。结论:TTR在s PE、FGR和s PE+FGR孕妇血清中表达下调,有望成为s PE及FGR发生的生物标志物。s PE合并FGR可能由s PE本身的病理变化引起,s PE与FGR有着共同的病理基础。
Objective: To investigate the relationship between thyrotrophin (TTR) and the pathogenesis of s PE and FGR. Methods: Totally 120 singleton pregnant women, who were inspected and hospitalized at Beijing Luhe Hospital affiliated to Capital Medical University from September 1, 2012 to February 1, 2015, were divided into four groups: FGR group, s PE group, s PE + FGR group and control group (30 cases each). TTR concentration was detected by ELISA. The age, gestational age, delivery time, gestational age, serum TTR concentration and other indexes in 4 groups were compared. Results: There were no significant differences in age, gestational age, parity and gestational age between the 4 groups (P> 0.05). The plasma TTR levels in FGR, s PE and s PE + FGR groups were significantly lower than those in control group (P <0.01). The level of TTR in serum of PE group was lower than that of FGR group, the difference was statistically significant (P <0.01). CONCLUSION: TTR is down-regulated in sera of s PE, FGR and s PE + FGR pregnant women and is expected to become a biomarker of s PE and FGR. s PE combined FGR may be caused by the pathological changes of s PE itself, PE and FGR have a common pathological basis.