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采用完全随机同期对照方法,对家兔桡骨节段性缺损动物模型,分别植入自制脱钙牙本质基质(DDM)、生物活性玻璃陶瓷(BGC)与脱钙牙本质基质复合物、脱钙骨基质(DBM)整复骨缺损,行X线观察及新骨钙磷元素动态变化的测定。结果显示:用DDM整复的骨缺损区在术后各程期的X线表现与DBM相似,第8周时新旧骨界线消失,髓腔再通;而DDM加BGC的骨整复区在第8周时虽然骨断端新旧骨的界线消失,但新骨的X线表现仍为一阻射团块;空白对照侧在术后8~12周X线表现为骨断端成锥形,断端间无骨性愈合。新骨X线能谱分析结果显示,DDM和DBM组内各程期Ca/P值有显著性差异(P<0.01);除DDM及DBM第12周时的Ca/P值外,3种材料各程期新骨Ca/P原子个数比与正常骨相比有显著性差异(P<0.01
A completely randomized simultaneous control method was used in this study. Rabbits with segmental radial segmental defects were implanted with DDM, bioactive glass ceramics (BGC) and decalcified dentin matrix composite, decalcified bone Matrix (DBM) Whole Defects, X - ray Observation and Dynamic Changes of Calcium and Phosphorus in New. The results showed that the X-ray manifestations of bone defect areas reconstructed with DDM were similar to those of DBM at each stage of postoperative. The boundaries of old and new bone disappeared and the medullary cavity recanalized at the 8th week. However, At 8 weeks, although the boundary between old bone and new bone disappeared, the X-ray of new bone was still a block. On the blank control side, the X-ray showed a conical fracture at 8-12 weeks after operation Boneless healing between the ends. X-ray spectrum analysis of new bone showed that there were significant differences in Ca / P in DDM and DBM groups (P <0.01). In addition to the Ca / P values of DDM and DBM at 12 weeks There was a significant difference in the number of Ca / P atoms between the new bone and the normal bone in different materials (P <0.01)