Strategies for targeting the DNA damage response for cancer therapeutics

• 作 者: Kathryn L.Brinkman
• 机 构: Department of Radiation Oncology,The Methodist Hospital Research Institute,Houston,TX 77030,USA.,
• 出 处: 癌症
• 发表日期: 2012年08期
• 关键词: targeting DNA repair maintain BRCA recognize genomic targeted PARP defects

The DNA damage response is critical for cells to maintain genome stability and survival. In this review, we discuss approaches to targeting critical elements of the DNA damage response for radiosensitization and chemosensitization. In addition, we also discuss strategies for targeting DNA damage response and DNA repair defects in cancer cells for synthetic lethality.

The DNA damage response is critical for cells to maintain genome stability and survival. In this review, we discuss approaches to targeting critical elements of the DNA damage response for radiosensitization and chemosensitization. In addition, we also discuss strategies for targeting DNA damage response and DNA repair defects in cancer cells for synthetic lethality.