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目的探讨性功能正常男性不育者睾丸和精液的超微病变，寻找可能致病的因素。方法制作患者睾丸、精液超薄切片，透射电镜下观察分析，结果①睾丸病变为生精细胞成熟障碍（3例）和精子形成异常（12例），后者主要病变在于顶体形成异常和核发育畸变。②精液中异常发现主要为大量末成熟和畸形精子释人精液中。畸形精子头部畸变类同睾丸超薄切片中所见，尾部缺陷在轴丝复合体异常及中段线粒体鞘解体。结论本组男性不有可能因素为遗传、幼年疾病（隐睾、腮腺炎等）、长期服用抗生育药物、棉籽油及生殖道传染。
Objective To investigate the ultrastructural lesions of testis and semen in infertile men with normal sexual function and to find the possible pathogenic factors. Methods The testes and sperm ultrathin sections were made and observed under transmission electron microscope. Results ① Testicular lesions were abnormalities of spermatogenic cells maturation (3 cases) and abnormal spermatogenesis (12 cases). The main lesion was the formation of abnormal acrosome and nucleus Developmental distortion. ② abnormal semen found mainly for a large number of mature and abnormal sperm release sperm. Deformity sperm head distortion similar to the testicular ultrathin section seen, tail defects in the axial filament complex abnormalities and the middle mitochondrial sheath disintegration. Conclusion This group of men are not likely genetic factors, juvenile diseases (cryptorchidism, mumps, etc.), long-term use of anti-fertility drugs, cottonseed oil and genital tract infections.