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目的探讨负压创面治疗对高龄高压电烧伤患者炎性反应的影响。方法高压电烧伤高龄患者78例,随机分为治疗组与对照组(n=39),对照组给予传统多次换药治疗,治疗组给予负压创面治疗。结果所有患者都完成治疗,未发现明显并发症。治疗组与对照组的总有效率分别为94.9%和79.5%,创面愈合时间分别为(17.23±6.44)d与(25.33±5.29)d,治疗组有效率明显高于对照组(P<0.05),创面愈合时间明显少于对照组(P<0.05)。治疗后两组血浆IL-6与IL-8水平较治疗前均呈现明显降低的趋势(P<0.05),组间比较治疗组血浆IL-6与IL-8水平明显低于对照组(P<0.05)。结论负压创面治疗高龄高压电烧伤患者能有效抑制炎性反应,促进创面愈合,整体疗效好,是一种较理想的创面修复的方法。
Objective To investigate the effect of negative pressure wound therapy on inflammatory response in elderly patients with high voltage electric burn. Methods 78 cases of elderly patients with high voltage electric burn were randomly divided into treatment group and control group (n = 39). The control group received traditional dressing change and the treatment group received negative pressure wound treatment. Results All patients completed the treatment without any significant complications. The total effective rates of the treatment group and the control group were 94.9% and 79.5%, respectively. The wound healing time was (17.23 ± 6.44) days and (25.33 ± 5.29) days, respectively. The effective rate of the treatment group was significantly higher than that of the control group (P <0.05) , Wound healing time was significantly less than the control group (P <0.05). After treatment, the levels of plasma IL-6 and IL-8 in both groups were significantly lower than those before treatment (P <0.05). The levels of plasma IL-6 and IL-8 in the two groups were significantly lower than those in the control group (P < 0.05). Conclusion Negative pressure wound treatment of elderly patients with high voltage electric burn can effectively inhibit the inflammatory response and promote wound healing, the overall effect is good, is a more ideal method of wound repair.