论文部分内容阅读
目的：探讨促红细胞生成素（ＥＰＯ）与早产儿贫血的关系。方法：采用放射免疫法检测１６例早产儿血清ＥＰＯ、血红蛋白（Ｈｂ）、红细胞压积比（φＲＢＣ）、网织红细胞计数（Ｒｅｔ）、股静脉氧分压（ＰｖＯ２）的动态变化。结果：①早产儿ＥＰＯ水平生后逐渐下降，第３周末最低，以后缓慢上升，但至第５周末仍低于成年男性水平。②当早产儿Ｈｂ下降引起组织缺氧时，ＥＰＯ水平增高，但增高的幅度明显低于成年男性。③ＰｖＯ２＜３７ｋＰａ时，ＥＰＯ浓度均上升。④胎龄越小，ＥＰＯ水平越低。结论：ＥＰＯ水平低下是导致早产儿贫血的主要因素，为应用重组人类促红细胞生成素（ｒｈＥＰＯ）治疗早产儿贫血提供了理论依据。
Objective: To investigate the relationship between erythropoietin (EPO) and anemia in premature infants. Methods: The dynamic changes of serum EPO, hemoglobin (Hb), hematocrit (φRBC), reticulocyte count (Ret) and PvO2 in 16 premature infants were detected by radioimmunoassay. Results: ① The level of EPO in premature infants decreased gradually after birth, the lowest in the third weekend, and then slowly increased, but still lower than that of the adult males by the end of the fifth week. ② Hypobemia premature infants caused by hypoxia, EPO levels increased, but the increase was significantly lower than adult men. ③PvO2 <3 7kPa, EPO concentrations were increased. ④ smaller gestational age, the lower the EPO level. Conclusion: The low level of EPO is the main factor leading to anemia in premature infants, which provides a theoretical basis for the treatment of anemia in preterm infants with recombinant human erythropoietin (rhEPO).