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目的了解河南省疫苗相关麻痹型脊髓灰质炎(Vaccine-Associated Paralytic Poliomyelitis,VAPP)病例发生情况,为其防控策略制定提供科学依据。方法对河南省2004-2013年的VAPP病例进行描述性分析。结果河南省2004-2013年共发生VAPP病例19例,VAPP发生率为0.14/100万,首剂服苗VAPP发生率为0.93/100万。VAPP病例男女性别比为8.5∶1,2~6月龄儿童占73.68%。73.68%的病例为首次服苗,服苗至麻痹平均时间间隔为23 d,随访均有残留麻痹。病例便标本病毒分型以Ⅱ型为主。结论 VAPP病例以低月龄、首次服苗儿童为主。应加强接种前预检工作,严格掌握禁忌症。同时适时调整脊灰疫苗免疫策略,减少或避免VAPP的发生。
Objective To investigate the incidence of Vaccine-Associated Paralytic Poliomyelitis (VAPP) in Henan Province and provide a scientific basis for its prevention and control strategy. Methods A descriptive analysis of VAPP cases in Henan Province from 2004 to 2013 was conducted. Results In 2004-2013, 19 cases of VAPP occurred in Henan Province. The incidence of VAPP was 0.14 / 1 million and the incidence of VAPP in the first dose was 0.93 / 1 million. The gender ratio of VAPP cases was 8.5: 1, accounting for 73.68% of children aged 2-6 months. 73.68% of the cases were the first service-taking vaccine. The average interval between the service and the paralysis was 23 days, with residual paralysis at follow-up. Case of the virus typing to type Ⅱ-based. Conclusion The cases of VAPP are mainly low-age and first-served children. Pre-vaccination should be strengthened before the work, strictly control contraindications. At the same time timely adjust polio vaccine immunization strategies to reduce or avoid the occurrence of VAPP.