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为平战时抢救休克病人的需要,我们在兄弟单位(143、405医院等)协助下,经两年较广泛而系统地实验研究,制造成功一种新型果胶类代血浆—苹果胶代血浆。经理化、药理实验证明,质量完全符合人造代血浆的要求,是一种良好的血浆代用品,1979年9月已正式进入临床试用。注射用苹果胶(Pectin—Malinum pro Injectione,IPM)是苹果胶代血浆的主要成分。其主要化学成分为a-D-多聚半乳糖醛酸甲酯钠,含—OCH_3为8.4%±,平均分子量2.2～3.2万者为低分子,1万左右为小分子。苹果胶为白色或黄白色粉末或颗粒,几乎无味,有吸湿性。在174～180℃时分解。水溶性比一般果胶类大,性质较稳定。苹果胶代血浆(Injectio Pectin—Malini Compositae,简称IPM-代血浆)为无色或
In order to meet the need of rescuing shock patients in peacetime, we successfully developed a new type of pectin-substitute plasma-apple gum substitute plasma with the help of our brother unit (143,405 hospitals and so on) after a relatively extensive and systematic experiment in two years. . Managerial, pharmacological experiments show that the quality in full compliance with the requirements of man-made plasma is a good plasma substitutes, in September 1979 has officially entered clinical trials. Pectin-Malinum pro Injection (IPM) is the main component of apple gum substitute plasma. Its main chemical composition is a-D- sodium polygalacturonate, containing -OCH_3 is 8.4% ±, the average molecular weight of 2.2 ~ 3.2 million for the low molecular weight, about 10,000 as small molecules. Apple gum is white or yellowish white powder or granules, almost tasteless, hygroscopic. At 174 ~ 180 ℃ decomposition. Water-soluble pectin than the general large, more stable nature. Inject gel plasma (Injectio Pectin-Malini Compositae, referred to as IPM-generation plasma) is colorless or