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2型糖尿病(T2DM)可增加多种恶性肿瘤的发病风险,如乳腺癌、结肠癌、胰腺癌等,但同时研究发现T2DM可降低前列腺癌(PCa)的发病风险,其影响PCa发病风险的主要因素包括:血糖水平、雄激素水平、前列腺癌特异抗原(PSA)水平、二甲双胍和胰岛素等。此外,近年来研究还发现这些因素同时也能增加PCa患者复发和死亡风险。本文就T2DM上述因素与PCa发病风险和预后关系做一综述。
Type 2 diabetes mellitus (T2DM) can increase the risk of multiple malignancies such as breast cancer, colon cancer, pancreatic cancer, but at the same time found that T2DM can reduce the risk of prostate cancer (PCa), which affects the risk of PCa Factors include: blood glucose levels, androgen levels, prostate cancer specific antigen (PSA) levels, metformin and insulin. In addition, recent studies have found that these factors can also increase the risk of recurrence and death in PCa patients. This article reviews the relationship between the above factors of T2DM and the risk and prognosis of PCa.