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巴比妥盐已用于控制头部外伤伤员的颅内压(ICP),减轻实验猴的卒中和脑循环骤停造成的缺血性脑损伤,但机理尚不清楚。下表简要归纳卒中、循环骤停后脑病变(PCAE)和头部外伤的某些不同点。巴比妥盐可能在特异的神经病理演变过程中,通过不同的机理起作用,了解这些不同点很有必要。一、卒中:球后阻断灵长类与猫的大脑中动脉所产生的病灶,其范围较人类大脑中动脉梗塞者大。80～90%的动物在阻断后造成大脑梗死,60～70%呈永久性神经功能损伤。实验性卒中引起ICP上升的幅度与梗死的大小相平行。如果2小时内解除血管
Barbiturates have been used to control intracranial pressure (ICP) of head trauma casualties and to reduce ischemic brain damage caused by stroke and cerebral circulation arrest in experimental monkeys, although the mechanism is unclear. The following table briefly summarizes some of the differences in stroke, post-cyclical brain injury (PCAE) and head trauma. Barbiturates may act through different mechanisms during a specific neuropathological evolution, and understanding these differences is necessary. First, the stroke: after the ball blocking the primates and cats generated by the middle cerebral artery lesions, its scope than human cerebral artery occlusion were large. 80-90% of animals block cerebral infarction and 60-70% have permanent neurological damage. The magnitude of the ICP rise in experimental stroke parallel to the size of the infarct. Remove blood vessels within 2 hours