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用异丙肾上腺素（ＩＳＯＰ）和非典型β受体激动剂ＢＲＬ３７３４４作用于大鼠脂肪细胞，测定所产生的ｃＡＭＰ含量，结果二种激动剂的量效曲线相似。ＩＳＯＰ和ＢＲＬ３７３４４的ＥＣ５０分别为２．３×１０－７ｍｏｌ·Ｌ－１和２．０×１０－７ｍｏｌ·Ｌ－１，二者的ＥＣ８０都是１０－６ｍｏｌ·Ｌ－１。在普萘洛尔（ＰＲＯＰ）和选择性β１受体阻断剂ＣＧＰ２０７１２Ａ存在的情况下，ＩＳＯＰ的作用被阻断，ＰＲＯＰ与ＣＧＰ２０７１２Ａ的ＩＣ５０分别为２．０×１０－７ｍｏｌ·Ｌ－１和５．０×１０－８ｍｏｌ·Ｌ－１。但ＰＲＯＰ及ＣＧＰ２０７１２Ａ却难以阻断ＢＲＬ３７３４４的作用，只有在很高浓度（１０－４ｍｏｌ·Ｌ－１）时才能阻断其作用。上述结果表明大鼠脂肪细胞上存在着β１受体和非典型的β受体。
Isoprenaline (ISOP) and atypical receptor agonist BRL37344 acting on rat adipocytes, the resulting cAMP content was measured, the results of the two agonist dose-response curves were similar. The EC50 values of ISOP and BRL37344 were 2.3 × 10-7mol·L-1 and 2.0 × 10-7mol·L-1, respectively, and the EC80s of both were 10-6mol·L-1. The effect of ISOP was blocked in the presence of propranolol (PROP) and the selective β1 receptor blocker CGP20712A with IC50s of 2.0 × 10-7 mol·L-1 and 5 for PROP and CGP20712A, respectively .0 × 10-8mol·L-1. However, PROP and CGP20712A could hardly block the action of BRL37344, and blocked its action only at very high concentration (10-4mol·L-1). The above results indicate that β1 receptors and atypical β receptors exist on rat adipocytes.