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白癜风的发病学,现代倾向于与免疫介导的黑素细胞破坏有关。支持这一理论的证据有:白癜风常伴有其他自身免疫性疾病;血循中存在器官特异性自身抗体;证明有抗黑素细胞抗体以及白癜风皮损部位基底膜带有IgG及C_3的沉积。除此以外,白癜风的其他免疫学异常已越来越引起广大学者们的重视。本文就国外近几年来对白癜风其他有关免疫学异常的研究近况作一综述。一、T细胞与白癜风近来,随着单克隆抗体等新技木的开展应用,许多学者对白癜风病人的T细胞及亚群进行了研究。
The pathogenesis of vitiligo, modern tend to be associated with immune-mediated destruction of melanocytes. Evidence that supports this theory is that vitiligo is often accompanied by other autoimmune diseases, organ-specific autoantibodies present in the bloodstream, evidence of anti-melanocyte antibodies and deposition of IgG and C 3 in the basement membrane of the vitiligo lesions. In addition, other immunological abnormalities of vitiligo have attracted more and more scholars’ attention. This review summarizes recent research on other immunological abnormalities of vitiligo in foreign countries in recent years. First, T cells and vitiligo Recently, with the development of new technologies such as monoclonal antibodies, many scholars have studied vitiligo patients with T cells and subgroups.