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目的观察四联疗法治疗消化性溃疡合并幽门螺杆菌感染的临床疗效及其影响因素。方法将160例患者随机分为治疗组和对照组各80例,治疗组采用雷贝拉唑,阿莫西林、呋喃唑酮、果胶铋四联疗法。对照组采用雷贝拉唑,阿莫西林、呋喃唑酮三联疗法,比较两组临床疗效、不良反应及影响四联疗法治疗效果的因素。结果总有效率治疗组为95.0%,对照组为72.5%,两组比较差异有统计学意义(P<0.05),Hp的根除有效率治疗组为91.2%,对照组为71.3%,两组比较差异有统计学意义(P<0.05)。两组患者均未见明显不良反应。饮酒习惯、治疗前疼痛发作次数频繁、食欲减退、治疗后疼痛持续的天数较多等因素对溃疡的愈合有延缓作用;性别、年龄、病程、溃疡复发次数、每次疼痛持续时间等因素对溃疡的愈合无明显影响。结论以雷贝拉唑加铋剂为基础的四联疗法,疗效可靠,Hp根治率高,毒副作用小,值得临床推广使用。
Objective To observe the curative effect and influencing factors of quadruple therapy on peptic ulcer with Helicobacter pylori infection. Methods 160 patients were randomly divided into treatment group and control group of 80 cases, the treatment group with rabeprazole, amoxicillin, furazolidone, bismuth pectate quadruple therapy. The rabbits in the control group were treated with rabeprazole, amoxicillin and furazolidone triple therapy, and the clinical efficacy, adverse reactions and factors affecting the effect of quadruple therapy were compared between the two groups. Results The total effective rate was 95.0% in the treatment group and 72.5% in the control group, with significant difference between the two groups (P <0.05). The effective rate of Hp eradication group was 91.2% in the treatment group and 71.3% in the control group The difference was statistically significant (P <0.05). No significant adverse reactions in both groups of patients. Drinking habits, the frequency of pre-treatment pain episodes, loss of appetite, prolonged post-treatment pain and other factors have a delaying effect on ulcer healing; sex, age, duration, the number of ulcer relapse, duration of each pain and other factors on ulcer No significant effect of healing. Conclusion The rabeprazole plus bismuth-based quadruple therapy has the advantages of reliable curative effect, high cure rate of Hp and small toxic and side effects, which is worthy of clinical promotion.