论文部分内容阅读
硝硫氰胺(4—硝基—4′异硫氰基二苯胺,Ni thiocyami n um7505)国内由湖北省医药工业研究所首次合成。经几年来大量临床应用证明,该药治疗血吸虫病具有较好效果。但也发现硝硫氰胺可以在2—8％的病人诱发不同程度的黄疸,肝功能损害者则较黄疸更为多见。发病机制尚未完全阐明。最近,我们在四川省广汉县对1979—1980两年内服用硝硫氰胺后出现黄疸及肝功能损害的33名慢性日本血吸虫病人进行了细胞免疫试验的检查,试图对发病机制中是否存在过敏因素作一探讨,现将结果报道如下。
Nitrosamine (4-nitro-4 ’isothiocyanatodiphenylamine, Ni thiocyami n um7505) was first synthesized by the Hubei Provincial Institute of Pharmaceutical Industry. After a large number of years of clinical application that the drug treatment of schistosomiasis has a good effect. However, it has also been found that nitrites can induce jaundice to varying degrees in 2-8% of patients, whereas jaundice is more common in those with impaired liver function. The pathogenesis has not been fully elucidated. Recently, we conducted a cell-mediated immunoassay in 33 chronic Schistosoma japonicum patients with jaundice and hepatic dysfunction after taking thiocyanate in 1979-1980 in Guanghan County, Sichuan Province, trying to determine whether there is an allergic factor in the pathogenesis For a discussion, the results are reported below.