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先证者Ⅲ_3,男性、46岁。患者从30岁始无诱因自感四肢发硬,双手不自主震颤,右手为重。在静止和情绪激动时震颤明显,书写困难。走路不稳。并相继出现语言不清、流涎、多汗。上述症状进行性加重。口服安坦、左旋多巴症状明显减轻。神经系统检查:精神欠佳,面部表情呆滞,语言缓慢,口吃。头、颈、躯干前倾,双上肢屈曲,两手轻微搓丸样动作,慌张步态,四肢肌张力呈齿轮样增强,腱
Probation III_3, male, 46 years old. Patients from the age of 30, no incentive to start their own limbs stiff, hands involuntary tremors, right hand is heavy. Tremor at rest and emotionally significant, writing difficulties. Walk instability. And one after another language is not clear, salivation, sweating. The above symptoms progressive increase. Oral Antu, levodopa symptoms significantly reduced. Nervous system examination: poor psychology, sluggish facial expressions, slow language, stuttering. Head, neck, trunk anteversion, double upper limb flexion, both hands rub the pellet-like action, panic gait, limb muscle tone was gear-like enhancement, tendon