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海州常山(Clerodendron trichotomum Thumb.)为馬鞭草科(Verbenaceae)植物,其叶有降低血压作用.作者等从叶中分离出一种新黄酮甙結晶,命名为海常素(clerodendrin),分子式C_(27)H_(26)O_(17)·3(1/2)H_2O,熔点215℃(分解),不含甲氧基;从物理化學性貭知属于黄酮甙类.水解后,得甙元分子式C_(15)H_(16)O_5·(1/2)H_2O,熔点347℃(分解),并得三乙酰化物,分子式C_(21)H_(16)O_8,熔点182℃;这二化合物証明为洋芹子素(apigenin)及其乙酰化物.所接糖証明为葡萄糖醛酸.从甲酯的制备及水解后甙元的定量測定,知其含有二分子葡萄糖醛酸,并經証实均連接在7位上.海常素的結构应为(Ⅰ)式.此外还分得熔点为220℃及235℃的二种結晶,前者經鉴定为中肌醇;后者为生物碱,但因量少未进行鉴定.
Clerodendron trichotomum Thumb. is a Verbenaceae plant whose leaves have a hypotensive effect. The authors isolated a new flavonoid crystal from the leaves, named clerodendrin, formula C_ (27)H_(26)O_(17)·3(1/2)H_2O, melting point 215°C (decomposition), free of methoxy; known from physicochemical properties as flavonoids. Molecular formula C_(15)H_(16)O_5·(1/2)H_2O, melting point 347°C (decomposition), triacetylated compound, molecular formula C_(21)H_(16)O_8, melting point 182°C; It is apigenin and its acetylated compound. The attached sugar is proved to be glucuronic acid. From the preparation of methyl ester and the quantitative determination of the aglycon after hydrolysis, it is known that it contains two molecules of glucuronic acid, and it has been confirmed Connected to the 7-position. The structure of the hyacin should be (I). In addition, two crystals having melting points of 220° C. and 235° C. are identified. The former is identified as mesositol and the latter is an alkaloid, but Less is not identified.