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利用邻香草醛缩4-氯邻氨基苯酚Schiff碱(H2L)和正丁基三氯化锡反应,合成了一个Schiff碱正丁基锡配合物(C1),通过元素分析、FT-IR、~1H NMR、~(13)C NMR以及X-射线单晶衍射对合成的有机锡Schiff碱配合物C1进行了表征。研究了配合物(C1)的紫外可见光谱,并且运用MTT方法,研究了该有机锡Schiff碱配合物对癌细胞的体外抑制活性,研究的结果显示,该有机锡Schiff碱配合物C1对MCF7、NCI-H460的抑制活性相比卡铂要更优越,因而可以考虑经过化学优化后,作为抗癌药物的备选化合物。
A Schiff base n-butyltin complex (C1) was synthesized by the reaction of o-vanillin aldehyde 4-chloro-o-aminophenol Schiff base (H2L) and n-butyltin trichloride. Elemental analysis, FT- ~ (13) C NMR and X-ray single crystal diffraction were used to characterize the synthesized organotin Schiff base complex C1. The UV-vis spectra of the complex (C1) were studied. The MTT method was used to study the inhibitory activity of the organotin Schiff base complex on cancer cells in vitro. The results showed that the organotin Schiff base complex (C1) The inhibitory activity of NCI-H460 is superior to carboplatin, so that it can be considered as an alternative compound for anticancer drugs after chemical optimization.