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系统性红斑狼疮 (ＳＬＥ)是自身免疫病的原型 ,其最重要特征是血清中出现以抗双链ＤＮＡ(ｄｓＤＡＮ)、抗Ｓｍ等为主的致病性抗核抗体 (ＡＮＡ)。阐明抗ｄｓＤＮＡ和抗Ｓｍ抗体生成的机制 ,对了解ＳＬＥ发病机制有重要意义。虽然多种假说来解释ＡＮＡ生成的机理 ,但许多证据提
Systemic lupus erythematosus (SLE) is a prototype of autoimmune disease. Its most important feature is the emergence of pathogenic antinuclear antibodies (ANA) that are predominantly anti-dsDNA (dsDAN), anti-Sm, etc. in the serum. To elucidate the mechanism of anti-dsDNA and anti-Sm antibody generation is of great importance for understanding the pathogenesis of SLE. Although many hypotheses are explaining the mechanism of ANA production, many evidence suggests