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目的观察高尿酸血症(HUA)与2型糖尿病(T2DM)患者大血管病变及血清高敏C反应蛋白(hs-CRP)水平的关系。方法将249例T2DM患者分为T2DM合并HUA(n=98)及血尿酸正常(NUA)组(n=151)。全部对象记录病程、大血管病变史(大血管病变诊断标准：具有高血压、冠心病、脑动脉硬化3项任1项以上),测身高、体重,计算体重指数(BMI),收缩压(SBP)、舒张压(DBP)、腰围(WL)、取清晨空腹静脉血,测空腹血糖(FPG)、空腹C肽(FCP)、血尿酸、血脂谱：总胆固醇(TCH)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、糖化血红蛋白(HbA1 C)、血清hs-CRP水平；彩色超声仪测量颈动脉内膜中层厚度(IMT)及颈动脉斑块情况,血管多普勒检测肱踝指数(ABI)。结果①T2DM合并 HUA组患者BMI、WL、SBP、DBP、TCH、TG、LDL-C及hs-CRP均高于NUA组(P<0.05)；②与NUA组比较,T2DM合并 HUA组患者IMT增厚,颈动脉斑块、大血管病变发生率增加(P均<0.05),而ABI明显降低(P<0.05)。结论 T2DM合并 HUA组患者,颈动脉斑块发生率及大血管病变发生率增加；代谢紊乱及炎性反应参与了颈动脉斑块及大血管病变的形成。“,”Objective]To observe the relationship of hyperuricemia (HUA)with macrovascular disease and serum high sensitivity C-reactive protein(hs-CRP)level in patients with type 2 diabetes mellitus(T2DM).[Meth-ods]Totally 249 patients with T2DM were divided into T2DM with HUA group and normouricemia (NUA) group.The course of disease and the history of macrovascular disease(diagnostic criteria was one of hypertension, coronary disease and cerebral arteriosclerosis)were recorded.Body height and weight were examined.Body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP)and waistline(WL)were calculated. The fasting venous blood in the morning was collected.The fasting blood glucose(FPG),fasting C peptide(FCP), blood uric acid and blood lipids[total cholesterol(TCH),triglyceride(TG),low density lipoprotein(LDL-C),high density lipoprotein(HDL-C)],glycosylated hemoglobin(HbA1C)and serum hs-CRP were measured.Intima-media thickness(IMT)and atherosclerotic plaque were measured by color ultrasonography.Ankle brachial index (ABI)was detected by diabetic foot screening and diagnosing box.[Results]BMI,WL,SBP,TCH,TG,LDL-C and hs-CRP in T2DM with HUA group were higher than those in NUA group(P<0.05).Compared with NUA group,IMT in T2DM with HUA group was thickened,and the incidence of carotid atherosclerotic plaque and ma-crovascular disease were increased(all P <0.05),while ABI was decreased obviously(P <0.05).[Conclusion]The incidence of carotid atherosclerotic plaque and macrovascular disease in T2DM with HUA patients are in-creased.Metabolic disorder and inflammatory response may involve in the formation of carotid atherosclerotic plaque and macrovascular disease.