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目的 对比观察头孢噻肟（ＣＴＸ）与其他两种抗菌药物治疗方案对３０例血液病合并感染患者杀 菌活性（ＳＢＡ）及临床疗效。方法ＳＢＡ采用微量稀释法测定，临床疗效根据临床治疗登记表按三 级标准判定。结果与结论 头孢噻肟的临床反应最佳，杀菌作用时间维持较长，但对绿脓假单胞 菌和阴沟肠杆菌杀菌作用较差；呱拉西林（ＰＩＰ）与阿米卡星（ＡＮ）方案的抗菌谱广，但ＰＩＰ杀菌 作用时间较短，可考虑缩短给药间期，而ＡＮ可按一日一次给全日量的方案，以提高疗效减少不 良反应；头孢哌酮（ＣＰＺ）可主要用于绿脓假单胞菌感染，也可用于其它细菌的混合感染，但给药 间隔时间以一日三次为宜。
Objective To compare the bactericidal activity (SBA) and clinical efficacy of cefotaxime (CTX) and two other antimicrobial agents in treating 30 patients with blood-borne infection. Methods SBA was determined by microdilution method, clinical efficacy according to clinical treatment registration form according to three criteria. RESULTS AND CONCLUSION Cefotaxime had the best clinical response with longer duration of bactericidal action but less bactericidal effect on Pseudomonas aeruginosa and Enterobacter cloacae. Pripoxazole (PIP) and amikacin (AN) The antibacterial spectrum of the scheme is broad, but the bacteriocidal action time of PIP is short, and the administration period of the PIP can be shortened. However, the AN can be given to the full-day regimen once a day to improve the curative effect and reduce the adverse reactions; and cefoperazone (CPZ) For Pseudomonas aeruginosa infection can also be used for mixed infection of other bacteria, but the administration interval of three times a day is appropriate.