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作者叙述了一系列蛋白酶抑制剂对疟原虫发育和裂殖子侵入红细胞的效应。在1981年,Banyal等就已证明了从放线菌培养滤液中得到的蛋白酶抑制剂能够抑制诺氏疟原虫裂殖子在体外侵入红细胞。现在通过研究、作者发现用大于0.05mM的Leupeptin,TLCK和Pepstatin对疟原虫发育与裂殖子侵入红细胞有抑制作用。而aprotinin,antipain,α-1-抗胰蛋白酶及大豆蛋白酶抑制剂在0.5mM时对此都没有影响。但是1mM的TPCK,1mM的PMSF与0.15mM的chymostatin都能够抑制裂殖子侵入红细胞,而不影响寄生疟原虫的发育。这些结果表明了恶性疟原
The authors describe the effects of a series of protease inhibitors on the development of Plasmodium and the invasion of erythrocytes by merozoites. In 1981, Banyal et al. Demonstrated that protease inhibitors derived from actinomycete culture filtrates can inhibit the invasion of erythrocytes by P. norelzo merozoites in vitro. Now through the study, the authors found that inhibition of malaria parasite development and merozoite invasive erythrocytes by Leupeptin, TLCK and Pepstatin at greater than 0.05 mM were found. While aprotinin, antipain, α-1-antitrypsin and soy protease inhibitors had no effect at 0.5 mM. However, 1 mM of TPCK, 1 mM of PMSF, and 0.15 mM of chymostatin all inhibited merozoite invasion into erythrocytes without affecting the development of parasitic malaria parasites. These results indicate falciparum falciparum