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目的 :探讨血浆氧化修饰低密度脂蛋白 ( OXLDL)水平的变化与 II型糖尿病 ( DM)伴脑梗死 ( CI)的关系。方法 :应用 ELISA法测定 DM伴 CI病人血浆 OXLDL的水平 ,另设单纯性 CI组 (不合并 DM)及正常对照组。结果 :( 1 )无论是否合并 DM,CI组病人血浆 OXLDL水平较正常对照组明显增高 ;且 DM伴 CI组明显高于单纯性 CI组。 ( 2 )血浆 OXLDL水平与 LDL-C、apo B水平呈正相关 ,而与 HDL -C水平呈负相关。结论 :OXLDL在DM伴 CI的发病过程中起重要作用 ,OXLDL水平升高可能是 CI发病的生化方面的危险因素之一。
Objective: To investigate the relationship between changes of plasma oxidized low density lipoprotein (OXLDL) and type II diabetes mellitus (DM) with cerebral infarction (CI). Methods: Plasma levels of OXLDL in DM patients with CI were measured by ELISA. A simple CI group (without DM) and normal control group were also established. Results: (1) The level of plasma OXLDL in CI group was significantly higher than that in normal control group with or without DM, and DM with CI group was significantly higher than that with simple CI group. (2) The level of plasma OXLDL was positively correlated with the level of LDL-C and apo B, but negatively correlated with the level of HDL-C. Conclusion: OXLDL plays an important role in the pathogenesis of DM with CI. Elevated OXLDL may be one of the biochemical risk factors of CI.