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以大黄水煎剂建立小鼠胃肠功能损害模型,探讨云芝提取物和其中的白桦脂酸对小鼠胃肠功能的影响以及白桦脂酸对小鼠在脂质过氧化方面的影响。研究结果表明云芝提取物和白桦脂酸能够较为显著地提高胃蛋白酶活性,增加胃泌素和胃酸分泌量(P<0.01);同时白桦脂酸高低剂量组能够明显降低小鼠血浆中丙二醛的含量,提高超氧化物歧化酶、谷胱甘肽过氧化物酶的活性以及肝脏匀浆中谷胱甘肽过氧化物的含量(P<0.01)。说明云芝提取物和白桦脂酸能够有效地改善小鼠的胃肠功能,且抗脂质过氧化是云芝活性成分白桦脂酸治疗作用机制之一。
The rhubarb decoction was used to establish the mouse model of gastrointestinal dysfunction and to explore the effect of the polysaccharides from Coriolus versicolor and its betulinic acid on the gastrointestinal function in mice and the effects of betulinic acid on lipid peroxidation in mice. The results showed that the extract of Coriolus versicolor and Betulinic acid could significantly increase pepsin activity and increase the secretion of gastrin and gastric acid (P <0.01). At the same time, betulinic acid high and low dose groups could significantly reduce the plasma concentration of propanediol Aldehyde content, increase superoxide dismutase, glutathione peroxidase activity and liver homogenate glutathione peroxidase content (P <0.01). The results showed that the extract of Coriolus versicolor and Betulinic acid can effectively improve the gastrointestinal function of mice, and the anti-lipid peroxidation is one of the mechanisms of action of betulinic acid.