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目的探讨注射用黄芪多糖辅助治疗小儿急性病毒性心肌炎(VMC)的临床疗效,并检测对其心肌酶的影响。方法选择嘉兴市第二医院儿科2013年1月-2016年1月急性VMC患儿158例,随机分为对照组和治疗组,两组各79例。对照组患儿进行常规治疗,治疗组患儿在常规治疗基础上给予注射用黄芪多糖治疗。评估治疗后临床疗效,记录患儿症状或体征、心电图恢及心肌酶恢复时间及住院时间。并检测患儿治疗前和治疗后血清心肌酶水平。结果治疗组患者临床疗效高于对照组,且治疗组患儿主要症状或体征、心电图和心肌酶恢复时间及住院时间均低于对照组(P<0.05)。治疗组患者治疗后磷酸肌酸激酶(CK)、磷酸肌酸激酶同功酶(CK-MB)、天冬氨酸转氨酶(AST)和乳酸脱氢酶(LDH)均低于对照组(P<0.05)。结论黄芪多糖针辅助治疗小儿急性病毒性心肌炎具有较好的临床疗效,能够显著缩短患儿的症状、体征及心肌酶改善时间,并显著降低患儿心肌酶的水平。
Objective To investigate the clinical efficacy of Astragalus polysaccharide injection in the treatment of children with acute viral myocarditis (VMC) and to investigate its effect on myocardial enzymes. Methods 158 children with acute VMC from January 2013 to January 2016 in Jiaxing Second Hospital were randomly divided into control group and treatment group, 79 cases in each group. Children in the control group were treated routinely. The children in the treatment group were given astragalus polysaccharide injection on the basis of routine treatment. Evaluate the clinical efficacy after treatment, record the symptoms and signs of children, restore ECG and myocardial enzyme recovery time and hospital stay. Serum levels of myocardial enzymes were measured before and after treatment. Results The clinical efficacy of the treatment group was higher than that of the control group. The main symptoms and signs, electrocardiogram and myocardial enzyme recovery time and hospital stay in the treatment group were lower than those in the control group (P <0.05). After treatment, the levels of creatine phosphokinase (CK), CK-MB, AST and LDH in the treatment group were lower than those in the control group (P < 0.05). Conclusion Astragalus polysaccharide acupuncture adjuvant treatment of children with acute viral myocarditis has a good clinical efficacy, can significantly reduce the children’s symptoms and signs and myocardial enzyme improvement time, and significantly reduce the level of myocardial enzymes in children.