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目的:探讨老年女性乳腺癌的临床特征及预后因素。方法:回顾性分析66例70岁以上年女性乳腺癌患者的临床资料及治疗效果。结果:全组患者1年生存率为100%,3年生存率为82.2%,5年生存率为73.0%。单因素分析显示,肿瘤分期、淋巴结转移、病理分子分型、有无手术和内分泌治疗是影响老年乳腺癌患者预后的主要因素。Cox多因素分析显示,肿瘤分期、淋巴结转移和有无手术是影响预后的独立因素。结论:老年女性乳腺癌具有独特的生物学特点,ER、PR阳性表达率高,肿瘤分期及淋巴结转移是影响预后的主要因素,所以早发现、早治疗可提高生存率。病理类型主要为浸润性导管癌,治疗应选择以手术为主的综合治疗,其中内分泌治疗占重要地位。
Objective: To investigate the clinical features and prognostic factors of breast cancer in elderly women. Methods: A retrospective analysis of 66 cases of women over the age of 70 years of breast cancer clinical data and treatment. Results: The 1-year survival rate was 100%, the 3-year survival rate was 82.2%, and the 5-year survival rate was 73.0%. Univariate analysis showed that tumor stage, lymph node metastasis, pathological molecular typing, with or without surgery and endocrine therapy are the main factors affecting the prognosis of elderly patients with breast cancer. Cox multivariate analysis showed that tumor staging, lymph node metastasis and the presence or absence of surgery were independent prognostic factors. Conclusion: Breast cancer in elderly women has unique biological characteristics. The positive expression rate of ER and PR is high, and the tumor stage and lymph node metastasis are the main factors affecting the prognosis. Therefore, early detection and early treatment can improve the survival rate. The main pathological type of invasive ductal carcinoma, the treatment should choose surgery-based comprehensive treatment, of which endocrine therapy occupies an important position.