论文部分内容阅读
目的:研究以芒、矾为中心离子配位络合对大鼠肠系膜血流的影响,探讨不同络合时间对血流影响的程度。方法:将30只SD大鼠随机分为第1、2、3组,每组10只,分别电离络合作用10 s、30 s、60s。观察比较同一区域3组大鼠电离络合作用前后肠系膜毛细血管交点数及通过毛细血管的红细胞数。结果:电离络合作用30s、60s后肠系膜的毛细血管交点数均减少,与同组络合前相比,差异具有统计学意义(P<0.05或P<0.01);电离络合作用10s、30s、60s后单位时间通过大鼠肠系膜毛细血管的红细胞数均减少,与同组络合前相比,差异具有统计学意义(P<0.05或P<0.01)。对于较细小的毛细血管,电离络合前血管内红细胞排列紧密,并能顺利连续通过,电离络合30s后血管内红细胞排列稀疏,不能连续通过血管,出现血流停滞、中断。结论:以芒、矾为中心离子络合可促使血栓形成,堵塞毛细血管,有效减慢甚至阻断大鼠肠系膜血流。
OBJECTIVE: To study the effect of ion-coordinate complex with Monascus and alum on the mesenteric blood flow in rats, and to explore the degree of influence of different complexation time on blood flow. Methods: Thirty SD rats were randomly divided into groups 1, 2 and 3, with 10 rats in each group. The animals were subjected to 10 s, 30 s and 60 s respectively. The number of mesenteric capillary intersections and the numbers of red blood cells passing through capillaries before and after ionization complexation in the same area were observed and compared. Results: The number of capillary junctions of mesentery decreased after 30s and 60s, respectively, with statistical significance (P <0.05 or P <0.01) before ionizing complexation After 60s, the number of erythrocytes passing through rat mesenteric capillary per unit time decreased, which was significantly different from that of the same group (P <0.05 or P <0.01). For smaller capillaries, intravascular erythrocytes were arranged closely before ionization and successfully passed continuously. After 30s of ionization, the intravascular red blood cells were sparsely arranged and could not continuously flow through blood vessels, causing blood flow stagnation and interruption. CONCLUSION: The ionic complexation with mangan and alum as the center can promote thrombosis, block the capillaries and effectively slow or even block the mesenteric blood flow in rats.