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对于因急性白血病,再生障碍性贫血或细胞毒药物作用而致粒细胞减少,从而引起细菌感染的病者,立即应用大剂量抗生素联合治疗往往有效。对于反应缓慢或者毫无反应者输入正常献血者或慢性粒细胞性白血病患者的粒细胞,对某些患者确有很大的效益。但是收集粒细胞并非易事,而且供者的粒细胞仅仅能贮藏1～2天,低温贮藏会失去功能。最重要的是可能出现各种副作用,如输入传染性疾病,诱致受者发生移植物抗宿主疾病,引起过敏反应和各种有害于肺部的作用。肺部的疾患可以由以下原因引起:液体负荷过度,粒细胞被扣留在广泛性损害的肺部,输入的粒细胞与循环中内毒素的相互作用可能导致休克肺综
For patients with bacterial infection caused by neutropenia due to acute leukemia, aplastic anemia or cytotoxic drugs, immediate and high-dose antibiotic combinations are often effective. In response to slow or no response to normal donor or chronic myelogenous leukemia in patients with granulocytes, in some patients do have great benefits. However, the collection of granulocytes is not easy, and donor granulocytes can only be stored for 1 to 2 days, cryogenic storage will lose its function. Most importantly, various side effects may occur such as the introduction of infectious diseases, the induced graft-versus-host disease in the recipient, the allergic reaction and various lung-damaging effects. Pulmonary conditions can be caused by excess fluid load, entrapment of granulocytes in extensively impaired lungs, and the interaction of imported granulocytes with circulating endotoxin that may result in shock pulmonary synthesis