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Dear Editor,rnWe are very glad to see that the Asian Journal of Andrology published a Special Issue on Semen Analysis in 21st Century Medicine, which well revealed some behind-the-scene controversies of the 5th edition of the WHO laboratory manual for the examination and processing of human semen [1]. Three articles from the special issue, two on the reference values of semen parameters [2,3] and another presenting the investigation results of 118 laboratories performing semen analysis in Mainland China [4], are very thoughtprovoking and we would like to share some of our views on these topics.