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系统性红斑狼疮(SLE)多见于女性。近来,动物和人的研究证明,激素可能在本病的临床表现中有重要的作用,因此控制激素水平可能有治疗价值。作者报道2例 SLE 患者,经炔羟雄烯异恶唑(danazol)治疗后获得临床改善。例1为31岁女性,患 SLE 11年,有关节痛,发热、皮疹、体重减轻和胸膜炎;血清 DNA 结合活性持续在90%以上(正常值30%)。需隔日服强的松龙25mg 控制复发性关节炎和胸膜炎。患者无肾脏病的证据。其关节痛和胸痛每在月经前数天加剧,即开始每天给予炔羟雄烯异恶唑400mg。在服药后9个月中,关节痛和胸痛改善,强的松龙剂量降至隔日7.5mg。在治疗过程中末发生任何严重副作用。
Systemic lupus erythematosus (SLE) more common in women. Recently, studies in animals and humans have shown that hormones may play an important role in the clinical presentation of the disease, so controlling hormone levels may have therapeutic value. The authors report 2 patients with SLE who achieved clinical improvement after treatment with danazol. Example 1 A 31-year-old female with SLE for 11 years with joint pain, fever, rash, weight loss and pleurisy; serum DNA-binding activity persisted above 90% (normal 30%). Need to take the next day strong prednisolone 25mg control of recurrent arthritis and pleurisy. No evidence of kidney disease in patients. Each of its joint pain and chest pain aggravate days before menstruation, that is, beginning with daily administration of alkyne androstane isoxazole 400 mg. In the first 9 months after taking the medication, joint pain and chest pain improved and the dosage of prednisolone reduced to 7.5 mg every other day. No serious side effects occurred during the treatment.