论文部分内容阅读
目的:分析恶性纤维组织细胞瘤(MFH)组织中HIF-1α和VEGF的表达及其与临床病理特征的关系,并探讨两者与预后的相关性。方法:回顾性分析山东省肿瘤医院2004-01-01-2007-01-01手术或者活检确诊的MFH患者52例,采用免疫组化SP法检测标本中HIF-1α和VEGF的表达,并分析两者与患者预后的相关性。结果:MFH组织中HIF-α和VEGF阳性率分别为67.31%(35/52)和73.08%(38/52)。HIF-1α的不同表达与临床分期有关,χ2=4.282,P=0.039;VEGF的不同表达与肿瘤的组织学分级、临床分期有关,χ2值分别为5.450和5.020,P值分别为0.020和0.025。HIF-α阴性者5年生存率(51.43%)比阳性(76.47%)者高,χ2=4.234,P=0.040;VEGF阴性者5年生存率(50.00%)比阳性(85.71%)者高,χ2=7.323,P=0.007。Cox回归模型多因素分析显示,分期、HIF-1α的表达是影响MFH患者预后的独立危险因素。结论:HIF-1α的表达与MFH患者的预后密切相关,可以作为一个指标来预测MFH患者预后。
OBJECTIVE: To analyze the expression of HIF-1α and VEGF in malignant fibrous histiocytoma (MFH) and its relationship with clinicopathological features, and to explore their relationship with prognosis. Methods: A retrospective analysis of 52 cases of MFH patients diagnosed by surgery or biopsy in Shandong Cancer Hospital from January 2004 to January 2007 was conducted. Immunohistochemical SP method was used to detect the expression of HIF-1α and VEGF. And the prognosis of patients with relevance. Results: The positive rates of HIF-α and VEGF in MFH tissues were 67.31% (35/52) and 73.08% (38/52) respectively. The expression of HIF-1α was related to the clinical stage (χ2 = 4.282, P = 0.039). The different expression of VEGF was related to the histological grade and clinical stage of tumor. The χ2 values were 5.450 and 5.020 respectively, and the P values were 0.020 and 0.025 respectively. The 5-year survival rate (51.43%) in HIF-α negative patients was higher than that in positive patients (76.47%) (χ2 = 4.234, P = 0.040) χ2 = 7.323, P = 0.007. Cox regression model multivariate analysis showed that staging, HIF-1α expression is an independent risk factor affecting the prognosis of MFH patients. Conclusion: The expression of HIF-1α is closely related to the prognosis of patients with MFH, which can be used as an index to predict the prognosis of patients with MFH.