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目的观察与分析换血治疗对新生儿高胆红素血症内环境血液学指标的影响。方法 42例新生儿高胆红素血症患儿作为研究对象,对全部患儿予以换血治疗,并对其治疗前后的内环境血液学指标变化情况加以观察与对比。结果换血后患儿的红细胞、血红蛋白、红细胞比容与换血前比较,差异均无统计学意义(t=-0.518、-1.884、-1.520,P>0.05);换血后的白细胞、血小板均低于换血前,差异均具有统计学意义(t=7.539、11.547,P<0.05)。换血后患儿的总胆红素、直接胆红素、间接胆红素、血糖水平与换血前比较,差异均有统计学意义(t=11.509、3.788、11.000、-6.898,P<0.05)。换血后患儿的钠、钾、氯水平均优于换血前,差异均有统计学意义(t=17.426、12.926、6.255,P<0.05);换血前后钙水平比较,差异无统计学意义(t=0.275,P>0.05)。结论对新生儿高胆红素血症患儿采取换血治疗,效果显著,但在治疗过程中,需密切监测患儿的各项生命体征或血液学指标,从而确保疾病治疗的效果。
Objective To observe and analyze the effect of transfusions on the hematological indexes of neonatal hyperbilirubinemia. Methods A total of 42 neonates with hyperbilirubinaemia were enrolled in this study. Blood transfusions were given to all children and the changes of the hematological parameters before and after treatment were observed and compared. Results There was no significant difference in erythrocyte, hemoglobin and hematocrit before transfusion between the two groups (t = -0.518, -1.884, -1.520, P> 0.05). The white blood cells and platelets after transfusion were all lower than Before transfusions, the differences were statistically significant (t = 7.539, 11.547, P <0.05). After transfusions, total bilirubin, direct bilirubin, indirect bilirubin, blood glucose levels were significantly different from those before blood transfusions (t = 11.509, 3.788, 11.000, -6.898, P <0.05). The levels of sodium, potassium and chloride in blood transfusions were better than those before blood transfusions (t = 17.426, 12.926, 6.255, P <0.05). There was no significant difference in calcium levels before and after transfusions = 0.275, P> 0.05). Conclusion The treatment of transfusing blood in neonates with hyperbilirubinaemia is significant. However, in the course of treatment, the vital signs and hematological indexes of children should be closely monitored so as to ensure the effect of disease treatment.