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目的探讨卡维地洛对原发性高血压患者血压晨峰的影响。方法选治疗未达标的原发性高血压患者29例,分别进行24h动态血压监测,观察其服用卡维地洛(每晚睡前10mg)前后血压晨峰的变化,并进行对比。结果服用卡维地洛治疗后,患者晨醒后0.5h内血压较治疗前明显降低(P<0.01),且患者晨醒后0.5h内血压与晨醒前最后一次血压的差值也较治疗前明显降低(P<0.01)。结论卡维地洛可以有效降低原发性高血压患者的血压晨峰。
Objective To investigate the effect of carvedilol on the morning peak of blood pressure in patients with essential hypertension. Methods Twenty-nine patients with unqualified essential hypertension were selected and monitored for 24h ambulatory blood pressure. Changes of morning blood pressure before and after taking carvedilol (10mg per night before bedtime) were observed and compared. Results After treatment with carvedilol, the blood pressure within 0.5 h after morning awake was significantly lower than that before treatment (P <0.01), and the difference between the morning blood pressure and the last blood pressure before morning waking was also lower Before significantly lower (P <0.01). Conclusion Carvedilol can effectively reduce the peak morning blood pressure in patients with essential hypertension.