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心律失常是心脏疾病常见的病症之一,不仅引起心脏功能障碍还可引起心源性猝死。Micro RNAs(mi RNAs)是一类长度约22 nt的单链非编码RNA。MiRNAs广泛参与细胞增殖、凋亡、分化、氧化应激等病理生理过程。MiRNAs不仅与心肌梗死、心肌肥厚及心肌纤维化等疾病发生密切相关,更与多种心脏病理状态下心脏电重构和心律失常的发生密切相关。近年来越来越多的研究证实miR-1、miR-328、let-7、miR-26、miR-208a等在心律失常发生发展过程中发挥了重要作用,并有望成为心律失常预警、诊断和治疗的新靶点。在这里阐述了这些miRNAs在心房纤颤、室性心律失常及心肌纤维化发生中的作用及意义。
Arrhythmia is one of the common diseases of heart disease, which not only causes cardiac dysfunction but also causes sudden cardiac death. Micro RNAs (mi RNAs) are a class of single-stranded noncoding RNAs approximately 22 nt in length. MiRNAs are widely involved in pathophysiological processes such as cell proliferation, apoptosis, differentiation and oxidative stress. MiRNAs are closely related to not only myocardial infarction, cardiac hypertrophy and myocardial fibrosis, but also to cardiac electrical remodeling and arrhythmia under various cardiac pathologies. In recent years, more and more researches confirm that miR-1, miR-328, let-7, miR-26 and miR-208a play an important role in the development of arrhythmia and are expected to become the early warning and diagnosis of arrhythmia New target for treatment. Here we describe the role and significance of these miRNAs in the pathogenesis of atrial fibrillation, ventricular arrhythmia and myocardial fibrosis.