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脲酶(Urease,E.C.3.5.1.5)又称尿素酶或尿素酰胺水解酶。曾有体外试验报导,汞及其化合物对脲酶活性有较强的抑制作用。为了探索脲酶活性测定作为汞污染对人体健康影响监测指标的可能性,我们应用大鼠进行了体内试验研究。 试验用Wistar大鼠(由湖南医科大学实验动物中心提供)40只,体重在180～230克,雌雄各半,随机分为四组,每组10只。第Ⅰ组为对照组;第Ⅱ组为铅、镉、砷混合毒物组;第Ⅲ组为汞染毒组;第Ⅳ组为铅、镉、砷、汞联合毒物观察组。对照组给自来水,第Ⅱ组给铅(硝酸铅A.R)、镉
Urease (E.C. 3.5.1.5) is also known as urease or urea amide hydrolase. It has been reported in vitro experiments, mercury and its compounds have a strong inhibitory effect on urease activity. In order to explore the possibility of measuring urease activity as a monitoring indicator of the impact of mercury contamination on human health, we conducted in vivo rat studies. Forty Wistar rats (provided by Experimental Animal Center of Hunan Medical University) with a body weight of 180-230 g and half male and half were randomly divided into four groups (n = 10). Group I was the control group; Group II was the combination of lead, cadmium and arsenic; Group III was the mercury-exposed group; Group IV was the combination of lead, cadmium, arsenic and mercury. Control group to tap water, the second group to lead (lead nitrate A.R), cadmium