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目的 探讨肺癌细胞凋亡水平与肺癌发生、发展和预后的关系。方法 应用TUNEL法检测 12 4例人非小细胞肺癌组织、癌旁肺组织和 4 0例正常肺组织中细胞凋亡水平。结果 ( 1)肺癌组织细胞凋亡指数 (AI)明显低于癌旁肺和正常肺组织 (P <0 .0 1) ;( 2 )肺癌细胞凋亡水平与肺癌P TNM分期、淋巴结转移状态有密切关系 (P <0 .0 5 ) ,而与肺癌组织学类型、细胞分化程度、原发肿瘤大小、部位、患者性别、年龄以及吸烟与否均无明显关系 (P >0 .0 5 ) ;( 3 )肺癌患者肺癌细胞凋亡高水平组 5年生存率( 4 5 .5 7% )明显高于凋亡低水平组 ( 14 .69% ) (P <0 .0 1)。结论 细胞凋亡水平异常可能在肺癌发生、发展和预后中起重要作用。检测肺癌细胞凋亡水平有助于判断肺癌患者预后和指导术后治疗。
Objective To investigate the relationship between the apoptosis of lung cancer and the occurrence, development and prognosis of lung cancer. Methods TUNEL was used to detect apoptosis in 124 non-small cell lung cancer tissues, adjacent lung tissues, and 40 normal lung tissues. Results (1) The apoptotic index (AI) of lung cancer tissue was significantly lower than that in para-tumor lung and normal lung tissue (P <0.01); (2) The apoptosis of lung cancer cells was associated with P TNM stage and lymph node metastasis of lung cancer. There was no significant relationship (P > 0.05) between the type of lung cancer, the degree of cell differentiation, the size, location, patient gender, age, and smoking of lung cancer (P < 0.05). (3) The 5-year survival rate (45.7%) of the high-level apoptosis of lung cancer patients with lung cancer was significantly higher than that of the low-level apoptosis group (14.69%) (P < 0.01). Conclusion Abnormal apoptosis may play an important role in the occurrence, development and prognosis of lung cancer. Detection of apoptosis in lung cancer cells can help determine the prognosis of lung cancer patients and guide postoperative treatment.