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根据Crabbe等的方法合成Anordrin,同WHO提供的纯净Anordrin样本完全相同。把重2.7~3.6kg的Cynomolgus猴隔离2个月,并作结核试验。在隔离期后,分笼按规定标准饲养。每天收集放在笼子下面盘中的尿液,记录尿量和冲洗水的量,根据收集的尿液总量和浓度计算免疫反应孕二醉(卜PD)的排泄量。在月经周期第10~20天采血标本离心后血清在一70“C贮存作激素分析用。在给药前,根据阴道出血和尿I一PD曲线至少观察一个正常月经周
The synthesis of Anordrin according to the Crabbe et al. Method is identical to the pure Anordrin sample provided by WHO. Cynomolgus monkeys weighing 2.7-3.6 kg were isolated for 2 months and tested for tuberculosis. After the isolation period, sub-cage according to the required standard feeding. Daily collection of urine placed in the tray below the cage, the amount of urine and irrigation water were recorded, according to the total amount and concentration of urine collected from the immune response of pregnant women drunk (Bu PD) excretion. Sera from 10 to 20 days after the menstrual cycle were collected and centrifuged in a 70 ”C for hormone analysis before vaginal bleeding and urine I-PD curve to observe at least one normal menstrual cycle