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目的探讨孤立性纤维性肿瘤(SFT)的临床病理学特点、免疫学表型及鉴别诊断。方法对5例SFT进行临床病理学分析,并用免疫组化(S-P法)技术检测CD34、CD99、Vim Des CD68和S-100蛋白的表达。结果肿瘤主要由纤维母细胞样梭形细胞呈束状、编织状及席纹状排列,有丰富的胶原纤维及多量瘢痕形成,细胞无异型,核分裂少或无,CD34、CD99和Vim弥漫强阳性,而Des、CD68及S-100蛋白均阳性。结论SFT大多为良性,可以根据病理形态及免疫组化来加以诊断及鉴别诊断,当镜下出现细胞丰富、密集,细胞有异型性,核分裂相增多(>4个/10个HPF),明显的坏死和出血并侵犯周围组织时,要考虑恶性可能。
Objective To investigate the clinicopathological features, immunological phenotype and differential diagnosis of solitary fibrous tumor (SFT). Methods The clinicopathological features of 5 cases of SFT were analyzed. The expressions of CD34, CD99, Vim Des CD68 and S-100 protein were detected by immunohistochemistry (S-P method). Results The tumors mainly consisted of fibroblast-like spindle cells arranged in a bundle, braided and satiniform pattern with abundant collagen fibers and numerous scar formation. The cells were nonspecific, with or without mitotic division. The diffuse positive of CD34, CD99 and Vim , While Des, CD68 and S-100 protein were positive. Conclusions Most of the SFTs are benign and can be diagnosed and differentiated according to the pathological morphology and immunohistochemistry. When the cells are abundant and dense, the cells have atypia and the number of mitotic phases is increased (> 4 HPF / 10 HPF) Necrosis may be considered when necrosis and bleeding and violations of surrounding tissues.