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Objective To review the recent research progress in lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1)including its protein,ligands,expression and pathophysiological significance.Data sources Information included in this article was identified by searching of PUBMED (1997-2006) online resourcesusing the key term LOX-1.Study selection Mainly original milestone articles and critical reviews written by major pioneer investigators of the fieldwere selected.Results The key issues related to the LOX-1 protein as well as ligands for LOX-1.Factors regulating the expression ofLOX-1 were summarized.The pathophysiological functions of LOX-1 in several diseases were discussed.Conclusions Identification of LOX-1 and a definition of its biological role in pathophysiologic states provide deeperinsight into the pathogenesis of some cardiovascular diseases especially in atherosclerosis and provide a potentialselective therapeutic approach.LOX-1 is unlocking and drugs targeting LOX-1 might be a promising direction to explore.Chin Med J 2007;120(5):421-426
Objective To review the recent research progress in lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) including its protein, ligands, expression and pathophysiology significance. Data sources Information included in this article was identified by searching of PUBMED -2006) online resources using the key term LOX-1. Study selection Mainly original milestone articles and critical reviews written by major pioneer investigators of the fieldwere selected. Results The key issues related to the LOX-1 protein as well as ligands for LOX-1 .actors regulating the expression ofLOX-1 were summarized.The pathophysiological functions of LOX-1in several diseases were discussed.Conclusions Identification of LOX-1 and a definition of its biological role in pathophysiologic states provide deeperinsight into the pathogenesis of some cardiovascular diseases especially in atherosclerosis and provide a potentialselective therapeutic approach .LOX-1 is unlocking and drugs targeting LOX-1 might be a promising direction to explore. Chin Med J 2007; 120 (5): 421-426