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我们曾报道,通过侧脑室注射给予外源性环-磷酸腺苷(cAMP)可明显拮抗电针镇痛和吗啡镇痛的效应。cAMP的注射量在50～400微克范围内可观察到电针镇痛效应与剂量的的对数呈直线负相关。相反,脑室注射cGMP则可明显地加强电针镇痛和吗啡镇痛的效应。此外,通过埋藏痿管向大鼠缰核内注射cGMP或db eGMP,亦能加强电针镇痛,并可延缓电针耐受的发展。
We have reported that the administration of exogenous cyclic adenosine monophosphate (cAMP) via intracerebroventricular injection significantly antagonizes the effects of electroacupuncture and morphine analgesia. The injection of cAMP in the range of 50 ~ 400 micrograms of electroacupuncture analgesic effect can be observed with the dose of the logarithm showed a linearly negative correlation. In contrast, intracerebroventricular injection of cGMP significantly potentiated the effects of electroacupuncture and morphine analgesia. In addition, by injecting cGMP or db eGMP into the rat’s habenula by burying the impotence tube, it can also enhance the electroacupuncture analgesia and delay the development of electroacupuncture.