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目的:探讨肿瘤坏死因子启动子TNFα-238G/A、-308G/A基因多态性与子宫内膜异位症的相关性。方法:运用PCR-RFLP技术检测100例内异症组及100例对照组肿瘤坏死因子启动子TNFα-238G/A、-308G/A基因多态性。结果:内异症组TNFα-238G/G、G/A、A/A表型频率(%)分别为0.93、0.07、0,TNFα-238G、TNFα-238A基因频率(%)分别为0.965、0.035;内异症组TNFα-308G/G、G/A、A/A表型频率(%)分别为0.87、0.12、0.01,TNFα-308G、TNFα-308A基因频率(%)分别为0.93、0.07。TNFα-238G/A和TNFα-308G/A各种基因型频率和基因频率在两组间差异无统计学意义(P>0.05)。结论:TNFα-238G/A、-308G/A基因多态性与子宫内膜异位症无明显相关。
Objective: To investigate the relationship between TNFα-238G / A and -308G / A gene polymorphisms and endometriosis in tumor necrosis factor (TNF) promoter. Methods: The TNFα-238G / A and -308G / A polymorphisms of tumor necrosis factor (TNF) promoter in 100 cases of endometriosis and 100 cases of control group were detected by PCR-RFLP. Results: The frequencies (%) of TNFα-238G / G, G / A and A / A phenotypes in endometriosis group were 0.93,0.07,0, TNFα-238G and TNFα-238A gene frequencies were 0.965,0.035 ; The frequencies of TNFα-308G / G, G / A and A / A phenotypes in endometriosis group were 0.87,0.12,0.01, TNFα-308G and TNFα-308A gene frequencies were 0.93,0.07 respectively. There was no significant difference between the two groups in the frequencies of TNFα-238G / A and TNFα-308G / A (P> 0.05). Conclusion: The TNFα-238G / A and -308G / A polymorphisms have no significant correlation with endometriosis.