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目的探讨血清高敏促甲状腺激素在预测冠状动脉病变程度中的应用价值。方法选择罗山县人民医院经动脉造影确诊为冠状动脉病变(冠状动脉病变在50%以上)的患者82例,分别根据冠状动脉造影结果(病变支数)分为A(25例,单支病变者)、B(27例,2支病变者)、C(30例,左主干病变或3支及3支以上病变者)3组及根据Gensini积分结果分为Ⅰ(24例,Gensini积分1~20分)、Ⅱ(27例,Gensini积分21~40分)、Ⅲ(31例,Gensini积分40分以上)3组,并对A、B、C 3组和Ⅰ、Ⅱ、Ⅲ3组间血清高敏促甲状腺激素(hs TSH)、总胆固醇(TC)及低密度脂蛋白胆固醇(LDL-C)水平进行对比。结果 C组hs TSH、TC及LDL-C水平显著高于A、B2组(P<0.05),而B组hs TSH、TC及LDL-C水平显著高于A组(P<0.05)。Ⅲ组hs TSH、TC及LDL-C水平显著高于Ⅰ、Ⅱ组(P<0.05),而Ⅱ组hs TSH、TC及LDL-C水平显著高于Ⅰ组(P<0.05)。结论血清hs TSH水平随着冠状动脉病变的范围的扩大和狭窄程度的增加而逐步上升,可作为评估冠心病患者冠状动脉病变程度的重要参考指标。
Objective To investigate the value of serum hypersensitive thyroid hormone in predicting the severity of coronary artery disease. Methods 82 patients with coronary artery lesions (more than 50% of coronary artery lesions) were confirmed by arteriography in Luoshan People’s Hospital. A total of 82 patients with coronary artery lesions were divided into two groups according to coronary angiography (A, (27 patients with 2 lesions), C (30 patients with left main disease or 3 lesions with more than 3 lesions), and according to the results of Gensini score were divided into Ⅰ (24 cases, Gensini score 1 ~ 20 cases), Ⅱ (27 cases, Gensini score 21-40 points), Ⅲ (31 cases, Gensini score 40 points or more). The serum sensitivity of group A, B and C and group Ⅰ, Ⅱ and Ⅲ3 TSH, TC and LDL-C levels were compared. Results The levels of hs TSH, TC and LDL-C in group C were significantly higher than those in groups A and B2 (P <0.05), while the levels of hs TSH, TC and LDL-C in group B were significantly higher than those in group A (P <0.05). The levels of hs TSH, TC and LDL-C in group Ⅲ were significantly higher than those in group Ⅰ and Ⅱ (P <0.05), while the levels of hs TSH, TC and LDL-C in group Ⅱ were significantly higher than those in group Ⅰ (P <0.05). Conclusions Serum hs TSH levels gradually increase with the expansion of the extent of coronary lesions and the degree of stenosis, which can be used as an important reference index for assessing the severity of coronary lesions in patients with coronary heart disease.