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目的:观察r-tpa合并甘露醇治疗血管壁病变性脑梗死临床疗效。方法:将临床发病6 h以内的急性脑梗死患者随机分为治疗组与对照组,每组60例,治疗组用r-tpa合并甘露醇静脉滴注,对照组用川芎嗪注射液静脉滴注,对治疗组和对照组连续使用15天观察对照组和治疗组的临床疗效及神经功能恢复情况。结果:采用r-tpa合并甘露醇静脉滴注和川芎嗪静脉注射液疗效比较,治疗组总有效率93.33%,明显优于常规治疗组78.33%,两组差异有统计学意义(P<0.05)。两组患者治疗后CSS评分均显著低于治疗前,且治疗组明显低于对照组(P<0.05);两组患者治疗后ADL评分均显著高于治疗前,且治疗组明显高于对照组(P<0.05)。结论:r-tpa合并甘露醇治疗血管壁病变性脑梗死临床疗效显著,且对6个小时内没有出血倾向的血管病变性脑梗死安全实用,患者后期恢复效果良好。
Objective: To observe the clinical efficacy of r-tpa combined with mannitol in the treatment of vascular wall lesion. Methods: The patients with acute cerebral infarction within 6 hours after clinical onset were randomly divided into treatment group and control group, with 60 cases in each group. The patients in the treatment group were treated with intravenous drip of r-tpa combined with mannitol and the control group with ligustrazine injection , The treatment group and the control group for 15 days continuous observation of the control group and the treatment group clinical efficacy and recovery of neurological function. Results: The total effective rate of the treatment group was 93.33%, which was significantly better than that of the conventional treatment group (78.33%). The differences between the two groups were statistically significant (P <0.05) . After treatment, CSS scores of both groups were significantly lower than before treatment, and the treatment group was significantly lower than the control group (P <0.05); ADL score was significantly higher in both groups after treatment than before treatment, and the treatment group was significantly higher than the control group (P <0.05). Conclusion: The clinical efficacy of r-tpa combined with mannitol in the treatment of vascular wall cerebral infarction is significant, and it is safe and practical for patients with vascular degenerative cerebral infarction without hemorrhage within 6 hours.