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药品中硫酸鹽的限度試驗,中国药典中規定有兩种方法:第一法以N/10硫酸作比較,第二法以硫酸钾作比較。但药典在操作条件上的規定不具体,因此做出的混濁度,結果往往相差很大。如果标准品的混濁度相差大,就無法作为标准来测定药品中硫酸鹽的限度。为此,以中国药典的兩种方法为基础,做了一系列的比較,初步結果如下。一理論部份硫酸根的檢查原理是用加稀的氯化鋇水溶液与SO_4~-生成硫酸鋇微細混濁的方法来比較混濁度。Ba~(++)+SO_4~-→BasO_1↓硫酸鋇在水中、酸、硷中溶解度均極小,故以它为标准是很恰当的。为了避免檢品中所存在的杂質与Ba~(++)生成沉淀干扰檢查,故要求在溶液中加稀鹽酸,使它們在酸中溶
The limits of sulphate tests in pharmaceutical products are regulated by the Chinese Pharmacopoeia in two ways: the first method is compared with N/10 sulfuric acid, and the second method is compared with potassium sulphate. However, the pharmacopoeia’s regulations on operating conditions are not specific, so the resulting turbidity results often vary greatly. If the turbidity of the standard varies greatly, the limits of sulfate in the drug cannot be determined as a standard. To this end, based on the two methods of the Chinese Pharmacopoeia, a series of comparisons were made. The preliminary results are as follows. A theoretical part of the examination principle of sulfate is to compare the turbidity by adding a dilute aqueous solution of lanthanum chloride and SO 4 4- to form a fine turbidity of barium sulfate. Ba~(++)+SO_4~-→BasO1↓ barium sulfate has very low solubility in water, acid, and cesium, so it is appropriate to use it as a standard. In order to avoid impurities and Ba~(++) precipitates from interfering with the inspection, it is required that dilute hydrochloric acid be added to the solution to dissolve them in the acid.