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对羟基苯甲酸酯类常用的有甲酯、乙酯、丙酯、丁酯等数种,此外还有异丙酯、异戊酯、己酯、环己酯等等,其中以丁酯抑菌力较强,以甲酯在水中的溶解度较大(1∶500)。由于合并使用可以获得较好的抑菌效果,所以常用其混合酯如甲丙酯、甲乙酯等。甲酯别名“尼泊金M”(Nipagin M),乙酯别名“尼泊金E”(Nipagin E),丙酯别名“尼泊索M”(Nipasol M)或尼泊索(Nipasol),混合酯类一般通称为“尼泊金”。它们最初只用于食品及香粧品工业中,近年来才开始作为防腐剂应用于药剂。丙酯以0.05%(W/V)的浓度用为水剂的防腐剂,0.1%(W/V)用为乳膏及乳剂的防腐剂;甲酯以0.1～0.2%用作水剂之防腐剂,亦可
Parabens are commonly used in methyl, ethyl, propyl, butyl and so on several kinds, in addition to isopropyl, isoamyl, hexyl, cyclohexyl, etc., among them butyric antibacterial Strong force to methyl ester in water solubility (1: 500). As the combined use can get better antibacterial effect, so commonly used mixed esters such as methyl, ethyl and so on. Methyl ester aliases “Nipagin M,” ethyl ester aliases “Nipagin E,” propyl ester aliases “Nipasol M,” or nephelome Nipasol, commonly known as mixed esters, is called “paraben”. Originally used only in the food and cosmetics industry, they were only used as preservatives in pharmaceuticals in recent years. Propyl ester is used as a preservative in aqueous solution at a concentration of 0.05% (w / v), as a preservative in creams and emulsions at 0.1% (w / v); as a preservative in 0.1-0.2% Agent, but also