论文部分内容阅读
慢心利是一种新的抗心律失常药,它的结构和作用与利多卡因类似,属于Ib类,但可以口服。本文通过给同样的患者一次口服或一次静脉注射慢心利来研究其药物动力学,并将结果与多次口服给药所得的结果相互比较。受试的对象共10名(男、女各半),为慢性室性过早搏动(PVCS)的住院患者。年龄29～88岁,体重36～79kg。试验前至少停药一周,试验中不得同时用其他药物。研究分四步进行:(一)在给药前三天内,每名受试者用非卧床的心电图监测24h,得
Slow heart Lee is a new anti-arrhythmic drug, its structure and role similar to lidocaine, belongs to the class Ib, but can be taken orally. This article examines the pharmacokinetics of the same patient by oral or intravenous bolus injection, and compares the results with the results of multiple oral dosing sessions. A total of 10 subjects (half males and half females) were enrolled in this study. They were hospitalized patients with chronic ventricular premature beats (PVCS). Age 29 to 88 years old, weight 36 ~ 79kg. At least one week before the test, the test may not be used with other drugs. The study was divided into four steps: (a) within three days prior to dosing, each subject was monitored by ambulatory ECG for 24 h