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平喘酮是为了克服胡椒酮(Ⅰ)苦辣刺激味进行结构改造而得的新平喘药——消旋胡椒酮二聚体。其化学结构由于反应条件差异和构型异构体很难分离曾有Ⅱ～Ⅷ式的报道;对碱性缩合的胡椒酮产物多视为双胡椒酮(Ⅵ)。作者用钠/苯缩合得到 mp166～168℃针晶(即平喘酮),通过紫外、红外、核磁共振光谱和质谱确定其结构类型与 Carter(1926)用钠汞齐/稀醇制得的双薄荷酮(Ⅲ)(原文报道 mp157～159℃,按晶
Pagesterone is a new antiasthma drug, racemic piperonone dimer, obtained by structural modification to overcome the bitter taste of pepperone (I). Its chemical structure is difficult to separate due to the differences in reaction conditions and configurational isomers. There have been reports of II-VIII formulas; the basic condensation of the pepperone product is mostly seen as a double pepperone (VI). The authors used sodium/benzene condensation to obtain needle crystals (orthosterone) at mp166-168°C. The structure types were determined by ultraviolet, infrared, nuclear magnetic resonance spectroscopy and mass spectrometry, and they were obtained by Carter (1926) using sodium amalgam/alcohol. Menthone (III) (original report mp 157-159 °C, according to crystal