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目的：研究普乐林注射液对卒中型自发性高血压大鼠（ＳＨＲｓｐ）脑卒中的预防和治疗作用。材料和方法：将８０只８周龄（雌雄各半）ＳＨＲｓｐ随机分为普乐林 ２００ ｍｇ／ｋｇ，１００ｍｇ／ｋｇ及对照组，饮 １． ０％～１． ５％ ＮａＣｌ盐水。实验一：在高盐负荷开始即灌胃治疗，８周后断头处死，取颈动脉及脑组织做电镜检查。取脑组织光镜下检查脑卒中发生率。实验二：脑卒中发生后开始灌胃治疗，连续１０天。记录大鼠脑卒中临床表现分数及存活天数。结果：实验一：治疗后普乐林 ２００ ｍｇ／ｋｇ， １００ ｍｇ／ｋｇ组颈动脉电镜扫描和脑组织电镜透射观察组织病理结果均好于对照组；光镜下脑卒中检出率（４１．７％，５０．０％）也低于对照组（７６．９％）。实验二：治疗前脑卒中临床表现分数三组间相似，治疗后普乐林 ２００ ｍｇ／ｋｇ， １００ ｍｇ／ｋｇ组分数（０． ９５±１． ３９，２．４１±１．６５）均明显低于对照组（３．７７±０．２７）（Ｐ＜０．０１～０． ００１）。治疗期存活天数普乐林 ２００ ｍｓ／ｋｇ组（９． ７３±１．０３）及１００ ｍｇ／ｋｇ组（７．９３±２．６４）均长于对照组（５．３６±４．４５）（Ｐ＜０． ０５， Ｐ＞０． ０５）。脑与心脏重量?
Objective: To study the prophylactic and therapeutic effects of pullarin on stroke in stroke spontaneously hypertensive rats (SHRsp). MATERIALS AND METHODS: Eighty eight-week-old SHRsp mice (male and female) were randomly divided into 3 groups: Bupleurine 200 mg / kg, 100 mg / kg and control group. 0% ~ 1. 5% NaCl saline. Experiment 1: At the beginning of high salt load, intragastric administration was given. After 8 weeks, the rats were decapitated and the carotid arteries and brain tissues were examined electron microscopy. Take brain tissue under light microscope to check the incidence of stroke. Experiment 2: After the onset of stroke began gavage treatment for 10 days. Record the clinical performance score and survival days of stroke in rats. Results: Experiment 1: After treatment, pullulan 200 mg / kg, 100 mg / kg group were observed by electron microscopy and electron microscopy. The histopathological results were better than the control group. 7%, 50.0%) were also lower than the control group (76.9%). Experiment 2: Pre-treatment stroke clinical manifestations of the scores were similar among the three groups, after treatment Pululin 200 mg / kg, 100 mg / kg group (0.95 ± 1.39,2.41 ± 1.65) were Which was significantly lower than that of the control group (3.77 ± 0.27) (P <0.01-0.001). The survival days in treatment group were longer than those in control group (5.36 ± 4.45) (P <0.05) P <0.05, P> 0.05). Brain and heart weight?