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目的探讨白细胞介素-8(IL-8),白细胞介素-17(IL-17)在慢性阻塞性肺疾病(COPD)发生机制中的作用。方法采用酶联免疫吸附法(ELISA)对 COPD 急性发作期患者(23例)及正常对照组(21例)痰 IL-8、IL-17水平进行检测。结果 COPD患者急性发作期痰 IL-8、IL-17水平明显高于正常对照组(P<0.01)。COPD 患者痰中 IL-8与1秒率(FEV_1)呈显著负相关(r=-0.746,P<0.01)。COPD 患者及正常对照组痰中 IL-8与 IL-17均呈显著正相关(r=0.727,P<0.01;r=0.774,P<0.01)。结论 IL-8及 IL-17均参与了 COPD 的发病过程,且 IL-17与 IL-8在 COPD 发病过程中关系密切。IL-17可能多经由 IL-8发挥作用。
Objective To investigate the role of interleukin-8 (IL-8) and interleukin-17 (IL-17) in the pathogenesis of chronic obstructive pulmonary disease (COPD). Methods Serum levels of IL-8 and IL-17 in sputum were detected by enzyme-linked immunosorbent assay (ELISA) in 23 patients with acute exacerbation of COPD and 21 normal controls. Results The levels of IL-8 and IL-17 in sputum from patients with acute exacerbation of COPD were significantly higher than those from normal controls (P <0.01). There was a significant negative correlation between sputum IL-8 and FEV_1 (r = -0.746, P <0.01) in patients with COPD. There was a significant positive correlation between IL-8 and IL-17 in COPD patients and normal controls (r = 0.727, P <0.01; r = 0.774, P <0.01). Conclusion Both IL-8 and IL-17 are involved in the pathogenesis of COPD, and IL-17 and IL-8 are closely related to the pathogenesis of COPD. IL-17 may play a role via IL-8.