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目的探讨依赖还原型辅酶Ⅰ/Ⅱ醌氧化还原酶1(quinone oxidoreductasel,NQO1)基因非同义编码 SNP(C609T、C465T、G406C)与淮安汉族人群食管癌易感性的关系。方法采用1:1配对的病例-对照研究,选择淮安地区原发性食管癌患者和对照者各106例。采用 PCR-RFLP 和 AS—PCR 技术检测研究对象的基因型,比较不同基因型与食管癌易感性的关系。结果在对照组与病例组中均未检测到 NQ01 406C/C 基因型;未发现 NQO1 CA65T 多态性与淮安汉族人群食管癌易感性的关系;携带 NQ01 609T 等位基因的个体与对照组相比,其患食管癌的易感性升高(OR=4.76,95%CI=1.064～3.397)。结论 NQ01 C609T 基因多态可能与食管癌的发生有关。
Objective To investigate the relationship between SNP (C609T, C465T, G406C) and susceptibility to esophageal cancer in Huaian Han population. Methods A case-control study of 1: 1 pairing was used to select 106 patients with primary esophageal cancer in Huaian area and controls. PCR-RFLP and AS-PCR were used to detect the genotypes of the subjects and the relationship between different genotypes and the susceptibility to esophageal cancer was compared. Results No NQ01 406C / C genotype was detected in the control group and the case group. No association was found between the NQO1 CA65T polymorphism and susceptibility to esophageal cancer in the Huaian Han population. Compared with the control group, individuals carrying the NQ01 609T allele (OR = 4.76, 95% CI = 1.064 ~ 3.397). Conclusion NQ01 C609T gene polymorphism may be related to the occurrence of esophageal cancer.