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目的探讨大剂量维生素C联合二磷酸果糖治疗新生儿窒息合并心肌损害的临床疗效。方法选取2012年8月—2014年12月在新余市妇幼保健院进行治疗的102例新生儿窒息合并心肌损害患儿,根据患儿住院尾号的奇偶数分为A组与B组,每组51例。B组患儿采取常规疗法,A组患儿在常规方法治疗的基础上应用大剂量维生素C联合二磷酸果糖方法治疗,比较两组患儿的临床疗效、心肌酶谱〔血清肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、天冬氨酸氨基转移酶(AST)以及α-羟丁酸脱氧酶(α-HBDH)〕水平变化情况及不良反应发生情况。结果治疗后,A组患儿的总有效率高于B组,CK、CK-MB、LDH、AST以及α-HBDH水平低于B组,不良反应发生率低于B组,差异有统计学意义(P<0.05)。结论大剂量维生素C联合二磷酸果糖治疗新生儿窒息合并心肌损害的临床疗效显著,可有效降低心肌酶谱水平。
Objective To investigate the clinical efficacy of high-dose vitamin C combined with fructose diphosphate in the treatment of neonatal asphyxia with myocardial damage. Methods A total of 102 neonates with asphyxia and myocardial damage who were treated in Xinyu City Maternal and Child Health Hospital from August 2012 to December 2014 were selected and divided into A group and B group 51 cases. The patients in group B received conventional therapy. Group A was treated with high-dose vitamin C combined with fructose-diphosphate (PBS) on the basis of routine treatment. The clinical efficacy, myocardial enzymes (serum creatine kinase (CK ), CK-MB, LDH, AST, and α-HBDH, and Adverse reactions occurred. Results After treatment, the total effective rate in group A was higher than that in group B, the levels of CK, CK-MB, LDH, AST and α-HBDH were lower than those in group B, and the incidence of adverse reactions was lower than that in group B (P <0.05). Conclusion High-dose vitamin C combined with fructose diphosphate treatment of neonatal asphyxia with myocardial injury significant clinical effect, can effectively reduce the level of myocardial enzymes.